Seattle Area Chest Grand Rounds

27 y.o. resident physician with a problem in the middle of the night - Dr. Andy Luks

Ghadiali N, Teo LM, Sheah K.
Bedside confirmation of a persistent left superior vena cava based on
aberrantly positioned central venous catheter on chest radiograph.
Br J Anaesth. 2006 Jan;96(1):53-6. Epub 2005 Nov 25.

Pahwa R, Kumar A. “Peristent left superior vena cava: an intensivists experience and review of the literature.” South Med J 2003; 96(5): 529-31.

Sarodia BD, Stoller JK. “Persistent left superior vena cava: case report and literature review.” Respir Care 2000; 45(4): 411-6.

Schummer W, Schummer C, Frober R. Persistent left superior vena cava and central venous catheter position: clinical impact illustrated by four cases.” Surg Radiol Anat 2003; 25: 315-21.

Schummer W, Schummer C, Steenbeck J. “Central venous catheter in the left hemithorax – malpositioned?” J Cardio Vasc Anesth 2004; 18(4): 529-531.

Troost E, Gewillig M, Budts W. “Percutaneous closure of a persistent left superior vena cava connected to the left atrium.” Int J Cardiol 2006; 106(3): 365-6.

61 YO man with gradually progressive dyspnea and cough - Dr. David Park

Arch Intern Med. 1989 Mar;149(3):589-93. Pulmonary disease in progressive systemic sclerosis. A complication of gastroesophageal reflux and occult aspiration? Johnson DA, Drane WE, Curran J, Cattau EL Jr, Ciarleglio C, Khan A, Cotelingam J, Benjamin SB.

Tashkin DP, Elashoff R, Clements PJ, Goldin J, Roth MD, Furst DE, Arriola E,
Silver R, Strange C, Bolster M, Seibold JR, Riley DJ, Hsu VM, Varga J,
Schraufnagel DE, Theodore A, Simms R, Wise R, Wigley F, White B, Steen V, Read C, Mayes M, Parsley E, Mubarak K, Connolly MK, Golden J, Olman M, Fessler B, Rothfield N, Metersky M; Scleroderma Lung Study Research Group.
Cyclophosphamide versus placebo in scleroderma lung disease. N Engl J Med. 2006 Jun 22;354(25):2655-66.

World J Surg. 2005 Nov;29(11):1510-5. Outcomes of lung transplantation in patients with scleroderma. Massad MG, Powell CR, Kpodonu J, Tshibaka C, Hanhan Z, Snow NJ, Geha AS.

Trad S, Amoura Z, Beigelman C, Haroche J, Costedoat N, Boutin le TH, Cacoub
P, Frances C, Wechsler B, Grenier P, Piette JC. Pulmonary arterial hypertension is a major mortality factor in diffuse systemic sclerosis, independent of interstitial lung disease. Arthritis Rheum. 2006 Jan;54(1):184-91.

60 YEAR OLD MAN FOUND DOWN - CARRIE CHUN

Am J Med. 2006 Mar;119(3):e11-4. Severe tuberculosis sepsis in an immunocompetent patient. Bridges DA, Bedimo RG.

Arch Intern Med. 2001 May 28;161(10):1347-8. Septic shock and thrombotic microangiopathy due to Mycobacterium tuberculosis in a nonimmunocompromised patient. Pene F, Papo T, Brudy-Gulphe L, Cariou A, Piette JC, Vinsonneau C.

Crit Care Med. 1992 Jun;20(6):901-3. Hemodynamic confirmation of septic shock in disseminated tuberculosis. Ahuja SS, Ahuja SK, Phelps KR, Thelmo W, Hill AR.

Wyser C, Walzl G, Smedema JP, Swart F, van Schalkwyk EM, van de Wal BW. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest. 1996 Aug;110(2):333-8.

Muthuswamy P, Hu TC, Carasso B, Antonio M, Dandamudi N. Prednisone as adjunctive therapy in the management of pulmonary tuberculosis. Report of 12 cases and review of the literature. Chest. 1995 Jun;107(6):1621-30.

Thwaites GE, Nguyen DB, Nguyen HD, Hoang TQ, Do TT, Nguyen TC, Nguyen QH, Nguyen TT, Nguyen NH, Nguyen TN, Nguyen NL, Nguyen HD, Vu NT, Cao HH, Tran TH, Pham PM, Nguyen TD, Stepniewska K, White NJ, Tran TH, Farrar JJ. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med. 2004 Oct 21;351(17):1741-51.

31 yo man with shortness of breath - Ann Chen

Pieroni M, et al. Clozapine-induced hypersensitivity myocarditis.
Chest. 2004 Nov;126(5):1703-5.

Wehmeier PM, Heiser P, Remschmidt H. Myocarditis, pericarditis and cardiomyopathy in patients treated with clozapine. J Clin Pharm Ther. 2005 Feb;30(1):91-6. Review.

Murko A, Clarke S, Black DW. Clozapine and pericarditis with pericardial effusion. Am J of Psychiatry 2002;159:494.

Fineschi V, Neri M, Riezzo I, Turillazzi E. Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment. Int J Legal Med. 2004 Oct;118(5):307-9.

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71 yo Man With A Pleural Effusion--Chris Slatore

Ohbayashi H, et al. Granulocyte colony stimulating factor-producing diffuse malignant mesothelioma of pleura. Intern Med. 1999 Aug;38(8):668-70.

Ascensao JL, et al. Leukocytosis and large cell lung cancer. A frequent association. Cancer. 1987 Aug 15;60(4):903-5.

Shoenfeld Y, et al. Leukocytosis in non hematological malignancies--a possible tumor-associated marker. J Cancer Res Clin Oncol. 1986;111(1):54-8.

Herndon JE, et al. Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B. Chest. 1998 Mar;113(3):723-31.

Hansen J, et al. Environmental exposure to crocidolite and mesothelioma: exposure-response relationships. Am J Respir Crit Care Med. 1998 Jan;157(1):69-75.

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51 yo Man With Dizziness--Carrie Chun

JOHNSON AJ, McCARTY WR. The lysis of artificially induced intravascular clots in man by intravenous infusions of streptokinase. J Clin Invest. 1959 Sep;38:1627-43.

Goldhaber SZ, et al. Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion.
Lancet. 1993 Feb 27;341(8844):507-11.

Konstantinides S, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patients with major pulmonary embolism: results of a multicenter registry. Circulation. 1997 Aug 5;96(3):882-8.

Kucher N, et al. Massive pulmonary embolism. Circulation. 2006 Jan 31;113(4):577-82.

Madan A, Schwartz C. Echocardiographic visualization of acute pulmonary embolus and thrombolysis in the ED. Am J Emerg Med. 2004 Jul;22(4):294-300.

45 yo Male With Neutropenic Fevers--Ann Chen

Haupt HM, et al. Ara-C lung: noncardiogenic pulmonary edema complicating cytosine arabinoside therapy of leukemia. Am J Med. 1981 Feb;70(2):256-61.

Andersson BS, et al. Fatal pulmonary failure complicating high-dose cytosine arabinoside therapy in acute leukemia. Cancer. 1990 Mar 1;65(5):1079-84.

Jehn U, et al. Non-cardiogenic pulmonary edema complicating intermediate and high-dose Ara C treatment for relapsed acute leukemia. Med Oncol Tumor Pharmacother. 1988;5(1):41-7.

Kopterides P, et al. Cytarabine-induced lung injury: case report. Anticancer Drugs. 2005 Aug;16(7):743-5.

Larouche G, et al. Corticosteroids and serious cytarabine-induced pulmonary edema. Pharmacotherapy. 2000 Nov;20(11):1396-9.